Jeffrey Macklis Harvard University USA Macklis is the Max and Anne Wien Professor of Life Sciences in the Department of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, and Professor of Neurology Neuroscience at Harvard Medical School HMS and was founding Program Head, Neuroscience, Harvard Stem Cell Institute. He is Co Director of the Developmental and Regenerative Biology Ph.D. Program at Harvard University. He is an M.I.T. faculty member in the Harvard-Massachusetts Institute of Technology MIT Division of Health Sciences and Technology HST. His lab is directed toward both 1 understanding molecular controls and mechanisms over neuron sub-type specification, development, diversity, axon guidance-circuit formation, and degeneration in the cerebral cortex and 2 applying developmental controls toward both brain and spinal cord regeneration and directed differentiation for in vitro therapeutic and mechanistic screening. The lab focuses on neocortical projection neuron development and sub-type specification neural progenitor stem cell biology induction of adult cortical neurogenesis subtype specific axonal growth cone biology and directed neuronal subtype differentiation via molecular manipulation of neural progenitors and pluripotent cells ESiPS. He attended M.I.T. S.B. Bioelectrical Engineering S.B. Literature, Harvard Medical School Harvard-M.I.T. HST Program, and graduate school at M.I.T. within HST, a student of Richard L. Sidman. He was a postdoctoral fellow in developmental neuroscience at HMS, where he also trained clinically in Internal Medicine at Brigham and Women Hospital BWH and Neurology in the Harvard Neurological Training Program no longer clinically active. He is the recipient of a number of awards, including a Rita Allen Foundation Scholar Award, a Directors Innovation Award from the NIH Director Office, the CNS Foundation Award, a Senator Jacob Javits MERIT Award in the Neurosciences from NINDS/NIH, the CajalKrieg Cortical Discoverer Prize. He is an Allen Distinguished Investigator of the Paul G. Allen Frontiers Group, a Brain Research Foundation Fellow, and recipient of a 2017 NIH Pioneer Award from the Office of the NIH Director.

Michal Schwartz (born 1 January 1950) is a professor of Neuroimmunology at the Weizmann Institute of Science and is internationally acclaimed as a path-breaking scientist in the study of Neuro-immunology, introducing the dialogue between the immune system and the brain as novel and pivotal player in life-long brain function and repair. Prof. Michal Schwartz groundbreaking discovery has revolutionized the field of neurodegenerative diseases, and led to a transformation in searching treatments for Neurodegenerative diseases, Her immunotherapeutic approach to treat of harnessing the immune system to help brain to treat terminal neurodegenerative brain diseases such as Alzheimer Disease and Dementia, is currently in expedite process of development. In her pioneering studies, she has shown, against prevailing wisdom at the time, that the immune system supports a health brain function and is vital for healing and protecting the brain in case of injury or disease. Prof. Schwartz research has not only changed the accepted scientific dogma, but laid the foundation worldwide for developing new research and treatment approaches in the field of brain disease and neurodegenerative conditions, particularly Alzheimer Disease and Dementia.

Prof. Moussa Youdim founded the Department of Pharmacology at the Rappaport Faculty of Medicine at the Technion. He chaired the department from 1977 to 1994 and was the Finkelstein Professor of Life Sciences. He has held numerous prestigious academic positions in universities worldwide. Moussa is the Founder, Chief Scientific Officer, and President of Youdim Pharmaceuticals, the Scientific organizer of Cardiamit Ltd., the Scientific Founder of Avraham Pharmaceuticals, and the Chief Scientific Officer of Abital Pharma Pipeline Ltd. He is internationally renowned for his research on monoamine oxidases, brain iron metabolism, Parkinson disease, Alzheimer disease, and amyotrophic lateral sclerosis. He has worked on drug development for these disorders and has established the importance of monoamine oxidase and brain iron metabolism for brain function and dysfunction. His research at Oxford University led to the discovery of the first monoamine oxidase B inhibitor, l-deprenyl selegiline, as an anti-Parkinson drug and he developed the concept of neuroprotection. At the Technion, he developed the second generation of neuroprotective monoamine oxidase B inhibitor anti-Parkinson drug, Rasagiline Azilect with Teva Pharmaceuticals. He developed the first multifunctional neuroprotective anti-Alzheimer drug, currently designated Ladostigil , and novel multi-target neurorestorative M30 iron chelator and Exegiline series, which are under development for Parkinson and Alzheimer diseases at Youdim Pharmaceuticals. He holds over 100 drug patents, has published more than 900 scientific articles, edited 45 books, and sat on the editorial boards of 43 international scientific journals. In addition, he has received some 40 major national and international prizes and awards including honors from Iran, Israel, the United States, England, Germany, Denmark, Holland, and Switzerland. He has also received two honorary doctorate degrees from Semmelweis University, Hungry, and the University of Pisa, Italy. He is an elected member of Leopoldina, the German Academy of Sciences, and the Hungarian Academy of Sciences. He has received over 40 honors, awards, and prizes nationally and internationally. In 2010 he was awarded the European College of Neuropsychopharmacology Lifetime Achievement Award and the Israeli EMET prize for Brain Research. He has also received the International College of Neuropsychopharmacology Pioneering Award, the Arvid Carlsson Medal, and the Catecholamine Pioneering Award from the National Institutes of Health. He was elected an Honorary Member of the Israel Society for Neuroscience for his fundamental contributions to the field. In 2022 he received the Israel Prize in Life Sciences.

Susana J. Pasquare is full professor of Biological Chemistry II at Universidad Nacional del Sur UNS Argentina, professor in charge of two postgraduate courses at UNS, and 3) collaborating professor of the Diploma Course in Medicinal Cannabis at Universidad Nacional Arturo Jaureche UNAJ and a postgraduate course at the School of Medical Sciences of Universidad Nacional de La Plata. She is a researcher at Instituto de Investigations Bioquimicas de Bahia Blanca INIBIBB, an Argentinean research center depending on CONICET and UNS, where she is Director of the Laboratory of Cannabin ology and is also in charge of CONICET High Technological Level Service Determination of the composition of plant origin products and their derivatives. Her field of research on endocannabinoids was initiated in 2007 with a study on the endocannabinoid system ECS in physiological neurodegenerative processes in an in vivo normal aging model. She further studied ECS in pathological neurodegenerative processes in in vitro models of induced neuronal injury. A new line of research was also initiated in her lab for the study of ECS regulation in the visual process. At present her studies are centered on elucidating whether ECS is altered in the injury induced by or by high light intensity by exploring its regulation through the action of neuromodulators and complete extracts derived either from Cannabis sp. plant with different Phyto cannabinoid composition or from its pure active principles. She was awarded a Postdoctoral Research Fellowship granted by the Ministry of Education, Science and Technology Argentina Carolina Foundation Spain for a stay at Instituto Ramon Cajal, Madrid, Spain an Erasmus Teaching Staff Mobility Fellowship for a stay at University of Deist Spain and a prize and grant from Florencio Fiorina Foundation and the National Academy of Medicine Argentina to conduct research in Biomedical Sciences. She has extensive experience in human resource training, has been awarded several grants, is author of 44 publications in high impact journals, has been invited to lecture at several international and national scientific meetings, being in some of them member of their Scientific Committee and has been in charge of several evaluation commitments.

Dr. Howard E. Gendelman is the Margaret R. Larson Professor of Internal Medicine and Infectious Diseases, chairman of the Department of Pharmacology and Experimental Neuroscience and director of the Center for Neurodegenerative Disorders at the University of Nebraska Medical Center. Dr. Gendelman is credited with unraveling how functional alterations in brain immunity induce metabolic changes and ultimately lead to neural cell damage across a broad range of infectious, metabolic, and neurodegenerative disorders. These discoveries have had broad implications on developmental therapeutics aimed at preventing, slowing, or reversing neural maladies. He is also credited with demonstrating that AIDS dementia is a reversible metabolic encephalopathy. His work has led to novel immunotherapy strategies for Parkinson's disease that have been successfully tested in early clinical trials as a result of translational investigations.

Dr. Nagy has been working on the mechanisms involved in peripheral and spinal neuronal processing for 30 years. He has been particularly interested in the neurochemistry, physiology, and pharmacology of nociceptive processing. He has been working at Imperial College London since 1998, where he is one of the leading basic pain scientists. His pioneering work on heat transduction mechanisms and interactions between the endo vanilloid and endo cannabinoid systems has significantly contributed to the knowledge, which underlies the recent development of novel pharmacological approaches for pain control. He uses a broad repertoire of techniques including molecular, biochemical, and electrophysiological, pharmacological, morphological and behavioral approaches. Dr Nagy is the principal author of many highly-cited, seminal publications in peer-reviewed journals and books. He is a regularly invited speaker, key-note presenter and session organiser at various international conferences. As a principal investigator, Dr Nagy leads the work of a group of undergraduate and postgraduate students, as well as postdoctoral scientists. He has extensive collaboration with several academic and industrial scientists both within the UK and overseas.

Michel Barrot is a Research Director at CNRS and Director of the Institute des Neurosciences Cellulaires & Integrative INCI in Strasbourg, France. He did his Ph.D. training at INSERM and Bordeaux University in France, working on dopamine systems. After postdoctoral training in the Molecular Psychiatry department at Yale University, he was appointed Assistant Professor in the Psychiatry department at the UT Southwestern Medical Center at Dallas and then recruited for a tenure researcher position by the CNRS in France in 2003. Within INCI, he directs research projects on the treatment of, and the relation between, chronic pain and mood disorders and on the neuroanatomy and physiology of dopamine systems.

Juan Lerma is Vicepresident of the European Brain Council, Director of the Cajal International Neuroscience Center (CINC-CSIC) and Research Professor at CSIC. Professor Lerma is also Councilor of North American Society for Neuroscience (SfN) and Editor-in-chief of Neuroscience, the flagship journal of the International Brain Research Organization (IBRO) and one of the oldest publications in international neuroscience. He has been President of the Spanish Neuroscience Society (SENC) from 2011 to 2013; Chairman of the IBRO Pan-European Committee, 2013-16; and Secretary General of the Federation of European Neuroscience Societies (FENS), 2016-2018. He is a member of the European Academy; of the European Dana Alliance for the Brain (EDAB) and the European Molecular Biology Organization (EMBO).In 2016, Professor Lerma received the Gold Medal from the Institute of Neurosciences (CSIC-UMH) for his successful work as the head of the Institute.This recognition is in addition to other important national and international distinctions received throughout his research career. Research line:Director of the Synaptic Physiology group at the Institute of Neurosciences in Alicante, his line of research is related to the molecular bases of neuronal communication, specifically the mechanisms used by the neurotransmitter glutamate in synaptic transmission and brain plasticity, and its ability to trigger brain diseases when dysregulated. Lerma is one of the Spanish scientists whose work on the mechanisms that govern neuronal communication have had the greatest impact in the international level, and his research on neurotransmission processes broke new grounds in modern neuroscience.

Krueger received his Bachelor of Science from the University of Wisconsin, his doctorate in physiology from the University of Pennsylvania, and his Doctorem Medicinae Honoris Causa from the University of Szeged. From 1974-78 he served as a research fellow and then an instructor in the Harvard Medical School Departments of Physiology and Biochemistry, and from 1978-81 he was a research associate in Physiology. In 1981, he joined the Chicago Medical School Department of Physiology and Biophysics. He was an associate and full professor from 1985-97 at the Department of Physiology and Biophysics at the University of Tennessee. He joined WSU in 1997, and in 2007 was named a WSU Regents Professor. In 2010, Krueger received designation as Eminent Professor, the highest award given to WSU faculty. In 2012, he was named the WSU Honors College Faculty Thesis Advisor of the Year and elected to the Washington State Academy of Sciences.

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Dr. Kazuhide Inoue is the University Professor, The Institute for Advanced Studyof Kyushu University. Professor Inoue has published hundreds of papers on the subject of the function of purinergic receptors in CNS, especially in pain signaling. He found that P2X4 receptors in spinal microglia has important role in the expression of neuropathic pain that is often refractory to treatment with NSAIDs and opioids. In 1975, he graduated School of Pharmaceutical Sciences, Kyushu University, and 1978 he started to research at National Institute of Health Sciences, Japan. He studied abroad in NIH, USA as a visiting fellow from 1985 until 1987, and in University College London as an honorary research fellow from 1991 till 1992. In 2000, he became a professor of Graduate School of Pharmaceutical Sciences, Kyushu University. From 2014 till 2020, he worked as the Executive Vice-President of Kyushu University.He was awarded Science Technology Award from the Minister of Education, Culture, Sports, Science and Technology-Japan in 2007, the 3rd Setsuro Ebashi Prize of The Japanese Pharmacological Society in 2010, Medal from His Majesty the Spanish Emperor as an honor of Royal Academy of Pharmacy in 2010, The Pharmaceutical Society of Japan Award in 2013, and Medal with Purple Ribbon from His Majesty the Emperor in 2014.

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Dr. H. Hosseinkhani, Chemical Engineer, has broad experience in life sciences and is an expert in nanotechnology, biomaterials, drug delivery, 3D in vitro systems, bioreactor technology, and bioengineering stem cells technology. His working experience is mainly attributed to academia and industry of biomedical engineering research and development (which includes several years of basic science research experience in a number of premier institutions related to the structure and function of biomaterials, and in polymer-based and mineral-based medical implants development in the medical device industry). He has been awarded several prestigious fellowships including JSPS Fellowship of Japan, and European Marie Curie Fellowship. He authored more than 100 scientific papers published on peer-reviewed Journals, 5 books, and 10 book chapters (H-index: 46Google Scholar). He is inventor of 16 National and International patents, several of which are licensed to companies acting in the biomedical fields and translated to 7 commercial products. He is the founder of Matrix, Inc., a world leading Biotech Company dedicated to healthcare technology to improve patients quality of life.

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Anju Vasudevan, PhD is an Associate Professor of Neuroscience, Director of the Angiogenesis & Brain Development Laboratory, and Chair/Scientific Director of the Department of Neurosciences at Huntington Medical Research Institutes (HMRI), Pasadena, California. Dr. Vasudevan received her PhD in Neuroscience from the University of Cologne, Germany, and completed her postdoctoral work at Massachusetts General Hospital and Harvard Medical School. From 2007-2020, Dr. Vasudevan was a faculty member in the Departments of Neurology and Psychiatry at Harvard Medical School. Dr. Vasudevan established the Angiogenesis and Brain Development Laboratory (ABDL) in 2011, at McLean Hospital, which pursues basic and translational research in neuroscience. The ABDL moved to HMRI in 2020, and is also known as the Neurovascular Research Program here. Dr. Vasudevan work on early embryogenesis of the forebrain vascular system, and diversity of endothelial cell populations, has opened an entirely new conceptual framework from which to view this critical component of brain development. Her work has brought forth the new perspective that blood vessel-related defects from the brain earliest developmental stages can contribute to psychiatric disease origin. It underscored the importance of non-neuronal signaling via forebrain endothelial cells that is of new significance for neuropsychiatric illness. In addition, Dr. Vasudevan research program is tapping into the potential of embryonic forebrain endothelial cells to prevent the origin of psychiatric symptoms, by rescuing vascular defects in the prenatal brain, or by developing vascular therapies for repair and regeneration in the adult brain. This work has implications for understanding, prevention, and treatment of a variety of nervous system disorders like schizophrenia, autism, epilepsy, developmental delays, anxiety, and depression. Dr. Vasudevan is the recipient of the NARSAD Young and Independent Investigator Awards, and awards from the National Institute of Neurological Disorders and Stroke, and from the National Institute of Mental Health.

Junghyup Suh, PhD is an Instructor in the Division of Depression and Anxiety Disorders at McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA. Dr. Suh received his PhD in Developmental Neurobiology from Rutgers, the State University of New Jersey, and Robert Wood Johnson Medical School, and completed her postdoctoral work in the laboratory of Dr. Susumu Tonegawa, a Nobel laureate, at the Picower Institute of Learning and Memory, Massachusetts Institute of Technology. In 2016, Dr. Suh joined at McLean Hospital as a faculty member to pursue translational research in neuroscience. His overarching research interest is to advance our understanding of the neural principles underlying cognition and behavior, with a major focus on how traumatic experiences impact on the brain's stress and reward circuitry and ultimately increase vulnerability to drug addiction. His education and training have included in-depth experience with molecular and genetic techniques, systems neuroscience, and behavioral phenotyping. Using the whole of his foundational knowledge and broad technical expertise, he is particularly interested in how exposure to stress and alcohol alter neuronal activity and functional connectivity in the corticolimbic system and lead to the development of alcohol dependence and addiction. In this context, he has been actively performing optogenetic manipulation of neuronal circuits and cellular-resolution fluorescent calcium imaging techniques in freely behaving mice that are subjected to an array of behavioral assays. His research has been funded by the National Institute of Alcohol Abuse and Alcoholism.

Brittany Needham studied bacterial cell wall modification in the laboratory of M. Stephen Trent at University of Texas at Austin before working as a postdoctoral scholar at Caltech in the laboratory of Sarkis Mazmanian. Her research interests focus on the gut microbiome, which harbors astonishing genetic diversity, with over 22 million genes sequenced from human gut microbial populations, and an immense pool of unique enzymes capable of producing and modifying a wide array of chemical structural groups. Influence of this dense community, with its dynamic metabolic activity and bidirectional flux of molecules between microbe and host, extends beyond the gut into the entire body, including the brain. In fact, integration of molecular inputs from within the gut can shape animal health and behavior, with recent examples showing that an altered gut microbiota is sufficient to affect neurological and psychological symptoms in various mouse models. However, the mechanisms mediating gut-brain interactions remain poorly defined. Deeper understanding of the molecular communication between gut microbes and the central nervous system will uncover critical features of behavioral, psychiatric, and neurodegenerative diseases. Decoding the chemical messages between gut microbes and the host is the foundation of the research program of the Needham lab.

Graduate of Hebrew University Medical School in Jerusalem. Israel Residency in Pediatrics and adult neurology in Israel Residency in pediatric neurology at the Johns Hopkins Hospital, Baltimore USA, and consultant in neurology for the human genetic Moore clinic (head: VA \.McKusick ) Israeli board certification: Pediatrics; Neurology; Pediatric Neurology; Developmental medicine Former chairman of : Neurology, Meir Medical Ctr, Israel; The section of neurology, Tel-Aviv university; The ethical committee, Tel-Aviv University; The Israel society for pediatric neurology; The Israel society of adult neurology; The Israeli board of examiners in neurology Present: Professor (emeritus), the Sackler Faculty of Medicine, Tel-Aviv University; Chairman of neurology and the local review board, Mayne Hayeshua Med Ctr; The Israel Society for Clinical Neurophysiology Author of about 300 scientific papers and 10 book chapters Member of editorial board: Brain & Development; Int. J of Neurosurgery, J Pediatric Neurology (Turkey), Current Drug Therapy, Associated editor: Frontiers in Neurology, Frontiers in Psychiatry Reviewer of > 20 medical journals Main interests and research: Neurogenetics; Autonomic nervous system; neuromuscular disorders; epilepsy; Attention Deficit Disorder; Sleep

Jarred Griffin received his PhD from the Centre for Brain Research at the University of Auckland, New Zealand. His thesis investigated the development of an astrocyte-selective gene therapy vector to degrade chondroitin sulphate proteoglycans following spinal cord injury allowing for axon regeneration. He then used bipedal rehabilitative training to modulate neuroplasticity and further enhance functional recovery. Following his PhD, he joined the lab of Prof. Frank Brake at The German Center for Neurodegenerative Diseases where he continued his research of using rehabilitation as a combinatorial therapy after spinal cord injury. After recently receiving a German Research Foundation collaborative research grant, his research will expand how rehabilitation influences neuroplasticity and behavior and how it can be used in translational spinal cord injury studies.

Dr. Sungchil Yang achieved PhD in the department of molecular and integrative physiology, University of Illinois at Urbana & Champaign, studying a biophysical role of individual auditory neurons from cochlear nucleus to auditory cortex in auditory information processing under the supervision of Dr Albert S. Feng. Then, Dr Yang joined Helen Wills Neuroscience Institute of University of California at Berkeley as a postdoctoral fellow, studying mechanisms of an auditory phantom pain, tinnitus, with Dr Shaowen Bao. His research regarding the sensory system continued in Center for Integrative Neuroscience of University of California at San Francisco as a research associate, studying a role of axon initial segment of auditory neurons in information processing and a cellular basis of perceptual learning with Dr Kevin J. Bender and Christoph E. Schreiner, respectively. Then, he joined the Department of Neuroscience in City University of Hong Kong.

Audrey Lafrenaye is an Assistant Professor in the department of Anatomy and Neurobiology at Virginia Commonwealth University in Richmond VA, USA. Her background is in cellular and molecular neuroscience, with focuses on quantitative immuno histology, glial pathology (including microglia, astrocytes and oligodendrocyte), and central fluid percussion injury models to induce brain injury in both rats and pigs. The work in her laboratory focuses on evaluating the progression and molecular mechanisms involved in diffuse neuronal and glial pathologies following traumatic brain injury.

PROF. DR. CHRISTIAN SCHACHTRUP Im Winkel 2 79232 March E-mail: christian.schachtrup@anat.uni-freiburg.de Born 21st December 1973 in Münster Married, 2 Children (*31.1.2013, *29.2.2016) PROFESSIONAL EXPERIENCE 12/2017 – today Heisenberg Professor (tenured) Institute of Anatomy and Cell Biology, Albert-Ludwigs-Universität Freiburg Germany 07 2010122017 Research Group Leader Institute of Anatomy and Cell Biology, Albert-Ludwigs-Universität Freiburg, Germany Basic research in Neuroscience Neuronal regeneration at the neurovascular interface  Personnel and budget responsibilities University-level teaching duties: Teaching activities in Human Medicine and Molecular Medicine (Anatomy); Bachelor's and Master's courses in Biology 05/2008-05/2010 Postdoctoral Scientist Research group: Prof. Katerina Akassoglou; Gladstone Institute of Neurological Disease, University of California, San Francisco, USA Topic: „Molecular mechanisms of fibrin functions at the neurovascular unit“. 01/2005-04/2008 Postdoctoral Scientist Research group: Prof. Katerina Akassoglou; Department of Pharmacology, University of California, San Diego, USA Topic: „Molecular mechanisms of fibrin functions at the neurovascular unit“. 01/2004-09/2004 Visiting Scientist Research group: Prof. Hisatake Kondo; Department of Histology, Tohoku University, Sendai, Japan Topic: „Functional Analysis of fatty acid binding proteins in the immune response of brain microglia“. Curriculum Vitae Prof. Dr. Christian Schachtrup 01/2000-10/2003 Graduate Research Student Research group: Prof. Friedrich Spener; Institute of Biochemistry, Westfälische Wilhelms-Universität Münster, Germany Topic: „Functional analysis of fatty acid binding proteins of the lung with the the aid of inflammation and knockout approaches EDUCATION AND DEGREES 22.10.2003 Dr. rer. nat. (magna cum laude) 30.09.1999 Diploma Degree in Biology (very good) 1994-1999 Biology Studies - Major in Biochemistry Westfalische Wilhelms Universitat Munster Germany FELLOWSHIPS AND AWARDS 2017 Heisenberg Professor "Professor for Anatomy with a focus on experimental neuroregeneration”. Positive evaluation received in 2020. 2016 (granted) Heisenberg-Programme "Molecular mechanisms of neural stem cell differentiation in central nervous system disease with blood-brain barrier opening 2010 J. David Gladstone Institutes 2010 Postdoctoral Award of Excellence in Science. Gladstone Institute of Neurological Disease, University of California, San Francisco, USA. 2005-2007 DFG postdoctoral fellowship, Research Topic: „Molecular mechanisms of fibrin functions at the neurovascular unit“. 2004 DFG guest researcher fellowship Research Topic: „Functional Analysis of fatty acid binding proteins in the the immune response of brain microglia“. 2002 Unilever Stiftungsfond scholarship Research Topic: „Functional analysis of fatty acid binding proteins of the lung with the aid of inflammation and knock-out approaches“. REVIEWER ACTIVITIES Scientific journals: Glia – Arteriosclerosis, Thrombosis, and Vascular Biology – Biomolecules – Cell and Tissue Research – Cellular and Molecular Life Sciences – Acta Biomaterialia – Journal of Anatomy – Neurogenesis – Neuroscience – Molecular Neurobiology – Scientific Reports – Bioscience Reports – Biology Curriculum Vitae Prof. Dr. Christian Schachtrup Communications – Nature Cell Biology – Experimental Cell Research – Neuronal Regeneration Research – JOVE Funding agencies: Deutsche Forschungsgemeinschaft, Germany (DFG), Intra-CREATE (Singapore), The Dutch Research Council (NWO). PROFESSIONAL QUALIFICATIONS 2022 Fachanatom Anerkennung durch die Anatomische Gesellschaft 2021 Guest Editor of the Cell & Tissue Research Special Issue entitled Modulating Scar Formation For Improving Brain Repair From Coagulation & Inflammation to Cell Therapy”. 2019 Organizer of the International Freiburg Symposium MODULATING SCAR FORMATION FOR IMPROVING BRAIN REPAIR: FROM COAGULATION & INFLAMMATION TO CELL THERAPY". 2017 Praparieren für Anatomen Universitat Tubingen 2013 today Organisation of the Annual Retreat of the Institute of Anatomy and Cell Biology 2014-today Approved examiner of the Faculty of Medicine, University of Freiburg 2012 Certificate in University level teaching (Medizindidaktische Qualifikation I, Block 1 und 260 AE 2010 today Responsible project leader for animal experiments 2010 today Responsible project leader for working with genetically modified organisms 2003 Certificate for working with genetically modified organisms („Sicherheitsmaßnahmen und Arbeitsschutz bei gentechnischen Arbeiten“) SOCIETY MEMBERSHIPS Anatomische Gesellschaft Society For Neuroscience SFN Deutsche Multiple Sklerose Gesellschaft dmsg Verband Biologie, Biowissenschaften und Biomedizin in Deutschland VBIO Curriculum Vitae Prof. Dr. Christian Schachtrup SELECTED ORAL PRESENTATIONS Mechanisms of NSC differentiation: from Coagulation to Immunomodulation. Cambridge Centre for Myelin Repair Seminar Series. 30th June 2022. Invited Talk. Fibrinogen–induced BMP signaling modifying stem cell behavior in CNS disease. 13th BMP conference, virtual BMP forum. 28th July 2021. Invited Talk. Einfluss der Störung der Blut-Hirn-Schranke und von Fibrinogen auf neurale Stammzellen. 93. Kongress der Deutschen Gesellschaft für Neurologie (DGN). Berlin, Germany 2020. Symposium: Das Endothel im Fokus bei Gefäßplastizität und pathologischer Neovaskularisation. Invited Talk. Fibrinogen deposition in the subventricular zone stem cell niche induces neural stem cell differentiation into astrocytes via BMP receptor signaling. Anatomische Gesellschaft 114th Annual Meeting. Würzburg, September 25-27, 2019. Selected from Abstract. Modulating Scar Formation For Improving Brain Repair: From Coagulation & Inflammation To Cell Therapy. 1 st Freiburg Work Meeting 9th September 2019. Organizer Mechanisms of Neural Stem Cell differentiation in CNS disease with BBB opening. Institute of Analytical Chemistry, University of Regensburg, 2018. Invited Talk. Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions. Anatomische Gesellschaft 110th Annual Meeting. Würzburg, September 24, 2015. Selected from Abstract. The vascular-derived blood protein fibrinogen regulates the differentiation of adult neural stem cells into astrocytes after traumatic brain injury. 36th Annual Meeting of the German Society for Microcirculation and Vascular Biology (GfMVB). Münster, Germany, September 30 - October 02, 2014. Selected from Abstract The balance of Id3 and E47 determines BMP-induced adult neural stem cell differentiation into astrocytes after vascular damage. Anatomische Gesellschaft 109th Annual Meeting. Salzburg, Austria September 25, 2014. Selected from Abstract. Fibrinogen regulates the differentiation of adult neural stem cells into astrocytes after vascular damage. The Plasminogen Activation & Extracellular Proteolysis Gordon Research The conference, Ventura, USA, February 09-14 2014. Selected from Abstract. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-β after vascular damage. 27. Jahrestagung der Anatomischen Gesellschaft, Würzburg, Germany September 30, 2010. Selected from Abstract. Fibrinogen mechanisms and functions in nervous system repair. Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, USA, 2010. Ceremony lecture for the 2010 Postdoctoral Fellow Award. Fibrinogen mechanisms and functions in nervous system repair. Institute for Anatomy and Cell Biology, Department of Molecular Embryology, University of Freiburg, Freiburg, Germany January 22, 2010. Invited Seminar. Fibrinogen mechanisms and functions in nervous system repair. UCSF Neuroscience Graduate Program Scientific Retreat, Asilomar, CA, September 2009. Invited Seminar. Identification of fibrin as a novel inhibitor of neurite outgrowth: Implications in spinal cord injury. 36th Society for Neuroscience (SfN) Annual Meeting, Atlanta, USA, October 14-18 2006. Selected from Abstract. Fibrin deposition and axonal damage in spinal cord injury. 18th International Congress on Fibrinolysis and Proteolysis, San Diego, USA, August 27-31 2006. Selected from Abstract. Curriculum Vitae Prof. Dr. Christian Schachtrup BIBLIOGRAPHY 10 MOST IMPORTANT PUBLICATIONS 1. Conforti P, Mezey S, Nath S, Chu YH, Malik SC, Martínez Santamaría JC, Deshpande SS, Pous L, Zieger B, Schachtrup C. Fibrinogen Regulates Astrocyte Scar Border Formation after Vascular Damage. Glia, DOI: 10.1002/glia.24166. IF: 7,45 2. Malik SC, Sozmen E, Baeza-Raja B, Le Moan N, Akassoglou K, Schachtrup C. In vivo functions of p75NTR: challenges and opportunities for an emerging therapeutic target. Trends Pharmacol Sci, Review, 2021, 42:43. IF: 13,50 3. Pous L, Deshpande SS, Nath S, Mezey S, Malik SC, Schildge S, Bohrer C, Topp K, Pfeifer D, Fernández-Klett F, Doostkam S, Galanakis DK, Taylor V, Akassoglou K, Schachtrup C. Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling. Nat Commun. 2020, 11:630. IF: 12,12 4. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. 2017. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 96:1003-1012. IF: 14,02 5. Pfurr S, Chu YH, Bohrer C, Greulich F, Beattie R, Mammadzada K, Hils M, Arnold SJ, Taylor V, Schachtrup K, Uhlenhaut NH, Schachtrup C. 2017. The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development. Development. 144:3917-3931. IF: 6,1 6. Bohrer C, Pfurr S, Mammadzada K, Schildge S, Plappert L, Hils M, Pous L, Rauch K, Dumit V, Pfeifer D, Dengjel J, Kirsch M, Schachtrup K, Schachtrup C. 2015. The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes. EMBO J, 34:2804-19. IF: 10,75 7. Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Perez A, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. 2015. Nuclear pore complex remodeling by the cleaved p75 neurotrophin receptor regulates TGF-beta signaling and astrocyte scar formation. Nat Neurosci, 18:1077-80. IF: 14,98 8. Schachtrup C, Ryu JK, Helmrick M, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. 2010. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-β after vascular damage. J Neurosci 30:5843-5854. IF: 5.97 9. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson R, Haddad GG, Karin M. 2008. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453:807-811. IF: 44.958 10. Schachtrup C, Lu P, Jones LL, Lee JK, Lu J, Sachs BD, Zheng B, Akassoglou K. 2007. Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor. Proc Natl Acad Sci USA 104:11814-11819. IF: 9,81 Freiburg, 19.08.2022 Prof. Christian Schachtrup

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Mai-Lan Ho, MD, is an Associate Professor of Radiology at Nationwide Childrens Hospital and The Ohio State University, where she has served as Director of Radiology Research, Director of the Translational Neuroimaging Core, Director of the Advanced Neuroimaging Core, Faculty Lead of the Imaging Genomics Research Affinity Group, Chair of the Asian Pacific American Network, and Secretary of the Association for Staff and Faculty Women. She is a physician-scientist who specializes in translational advanced MRI, head & neck imaging, and neurogenomics. Dr. Ho is lead author of the textbook Neuroradiology Signs; editor of The AAWR Pocket Mentor and Pediatric Neuroimaging: State-of-the-Art and engages broadly in diversity, inclusion, and global outreach initiatives.

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Dr. Huile Gao received his PhD in Pharmaceutics from School of Pharmacy, Fudan University in 2013. Then he joined the West China School of Pharmacy, Sichuan University. Dr. Gao s research interests focus on the design, synthesis, characterization and evaluation of stimuli responsive nano materials for drug delivery to improve tumor and brain diseases treatment. He is the highly cited scientist Clarivate Analytics 2020 highly cited Chinese researcher Scopus and has published over 150 peer-reviewed articles with an H-index of 56. He served as editor of the books neurotoxicity of nano materials and nano medicines and Brain Targeted Drug Delivery Systems. He is now serving as Editorial Board Member of Acta Pharma ceutica Sinica B, Expert Opinion on Drug Delivery, International Journal of Pharmaceutics, Chinese Chemical Letters, Pharmaceutics, Current Drug Metabolism, etc.

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Alexandrina Nikova is a neurosurgical trainee at Evaggelismos General Hospital in Athens, Greece .She graduated in 2018 the Democritus university of Thrace. Since then she is a two -time winner of an international research award and author of one book. Alexandrina Nikova is a last year student at Democritus University of Thrace, Alexadnroupolis, Greece. She is also a member of the neurosurgical lab faculty of the university and assistant in the operations for 2,5 years. She was a volunteer in the neurological department (Montana, Bulgaria 2016) and a hospitalization guest at the department of neurosurgery (Zurich, Switzerland 2017). Currently she is chosen to be a mentor of Fundamental neuroscience for neuroimaging of Johns Hopkins. Her recent researches include the field of neuro-oncology, neurosurgery, traumatic brain injuries, forensic science, vascular neurosurgery and pediatric neurosurgery.

Brandon Lucke Wold was born and raised in Colorado Springs, CO. He graduated magna cum laude with a BS in Neuroscience and distinction in honors from Baylor University. He completed his MD/PhD Masters in Clinical and Translational Research, and the Global Health Track at West Virginia University School of Medicine. His research focus was on traumatic brain injury, neurosurgical simulation, and stroke. At West Virginia University, he also served as a health coach for the Diabetes Prevention and Management program in Morgantown and Charleston, WV, which significantly improved health outcomes for participants. In addition to his research and public health projects, he is a co-founder of the biotechnology company Wright-Wold Scientific, the pharmaceutical company CTE cure, and was a science advocate on Capitol Hill through the Washington Fellows program. He has also served as president of the WVU chapters for the American Association of Pharmaceutical Scientists, Neurosurgery Interest group, and Erlenmeyer Initiative Entrepreneur group. In addition, he has served as vice president for the graduate student neuroscience interest group, Nu Rho Psi Honor Society, and medical students for global health. He was an active member of the Gold Humanism Honor Society and Alpha Omega Alpha Honor Society. He is currently a member of the UF House Staff Council, Positive Culture Committee, Quality Improvement Committee, Board of Directors Alachua County Medical Society, and Accreditation Requirements Review Committee. He is married to Noelle Lucke-Wold and has two children. As a family, they enjoy running with their dogs, rock climbing, and traveling. In his spare time, Brandon frequently runs half marathons and 10ks together with is wife. Brandon also enjoys reading, playing piano, discussing philosophy, and playing chess. He is currently a Pgy5 neurosurgery resident at University of Florida pursuing endovascular enfolded training and was awarded the Dempsey Cerebrovascular Research Fellowship.

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Fadel Tissir graduated in Biology from University Sidi Mohammed ben Abdellah, Fes, Morocco and earned his MSc degree from Liege University and PhD from the Free University of Brussels, Belgium. He worked as a postdoc on genetic factors predisposing to psychiatric disorders at the University of Antwerp from 1998 to 2000. He moved medical University of Louvain in 2001 as senior post doc. He was appointed as Assistant Professor in 2005 and promoted to the rank of Associate professor in 2008 and full Professor in 2018. In parallel to his academic career, Fadel Tissir was appointed as Research Associate at the Belgian Funds for Scientific Research in 2005 and promoted to the rank of Senior Research associate in 2013 and Research Director in 2017. His research focusses on the cellular and molecular mechanisms implicated in development and diseases of the nervous system. He has been active in the field of developmental neuroscience for more 20 years with emphasis on the role of planar cell polarity PCP and cytoskeletal proteins. his team discovered core component of PCP signaling and engineered mutant mouse models for all PCP genes. This program was very successful and led to the identification of a fascinating and unanticipated link between the mechanisms that regulate epithelial PCP on the one hand and those underlying numerous neurodevelopmental processes one the other hand. Hismoved the field of PCP from a purely observational phenomenon related to the stereotypic organization of hairs and sensory bristles in insects to concepts that govern the early blueprint of the mammalian nervous system wiring. This paved the way to important developments in the fields of neurogenesis, neuronal migration, wiring of the nervous system and ependymal ciliogenesis. This series of original findings were published in high impact journals Tissir et al. Nature Neuroscience 2005, Zhou et al. Science 2008, Tissir et al. Nature Neuroscience 2010, Boutin et al. PNAS 2014, Qu et al. PNAS 2014 Chai et al., Nature Neuroscience 2014 Wang et al. Nature Communications 2016 Damiani et al. Nature Communications 2016, Aragona et al Nature 2020

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Dr. Uqbah Iqbal is a Socioeconomic Researcher at Research for Social Advancement. Winning Second Place in Malaysian Historical Essay Writing Competition 2013, he was the recipient of Research University Fellowship Scheme, Graduate on Time Award and Outstanding Student Award from Faculty of Social Sciences and Humanities as well as the Youngest Ph.D. in History Holder and the only Malaysian achieved a Ph.D. in History in conjunction with the 43rd Convocation of Universiti Kebangsaan Malaysia. He's authoring notable books/ebooks such as The Historical Development of the Malay Nationalism Before Independence, The Historical Development of the Malay Society Economic Nature During Pre-Colonial Era, The Historical Development of British Investment in Malaya Before the Second World War, The Historical Development of Foreign Investment in the Formation of the Malaysian Economy and Sejarah Pemikiran Pandang Ke Timur: Kepentingan Jepun Dalam Pembangunan Sosio-Ekonomi Malaysia (1906-1980). His publications have appeared in a wide range of international and national journals such as TAWARIKH, SUSURGALUR, Management and Administrative Sciences Review, Social and Basic Sciences Research Review, Jurnal Kemanusiaan, Jurnal Sejarah, Jurnal Pengajian Melayu, Jebat, International Journal of Social Science and Humanities Research, Asia Pacific Journal of Education, Arts and Sciences, Asian Social Science and Geografia. He's also actively in the editorial board such as Asian Social Science, International Journal of Art and Literature, International Journal of Archaeology and History, American Journal of Social Sciences, Asia Pacific Journal of Education, Arts and Sciences, Social Sciences, Humanities and Social Sciences, History Research and Pratidhwani the Echo. Through his involvement as a reviewer with the Nonfiction Authors Association, 15 of his reviewed books received Awards.

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