The Experimental Cardiology Laboratory is engaged in studying the pathophysiology and pharmacotherapy of congestive heart failure, ischemia-reperfusion injury and diabetes induced cardiomyopathy. Our objective is to understand the molecular and subcellular basis of cardiac dysfunction in experimental animals with or without various drug treatments. Furthermore, we wish to identify new targets for discovering improved therapies for treatment of heart disease. In particular, we are focussed to examine renin-angiotensin system, sympathetic nervous system, oxidative stress, intracellular Ca2+-overload and subcellular remodeling for the transition of cardiac adaptation (hypertrophy and dilation) to maladepletion (cardiac dysfunction and heart failure).